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In patients with kidney disease who had not yet been dialyzed, omega-3 fatty acid supplementation resulted in improvements in pulse wave velocity and serum triglyceride levels, suggesting that daily use may reduce the risk of cardiovascular events.

However, supplementation had no effect on albuminuria.

Omega 3

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“There is interest in the possible beneficial effects that omega-3 polyunsaturated fatty acids … might have on CRF”. Daniel Bunout, MD, of the Institute of Nutrition and Food Technology at the University of Chile, and colleagues wrote. “These fatty acids have pharmacological properties that can improve kidney function, such as anti-inflammatory effects and lowering blood pressure and triglyceride levels.”

The researchers added that previous research also suggests a benefit of omega-3 polyunsaturated fatty acids (PUFA) in albuminuria, highlighting that different studies have come to different conclusions.

“The causes for these conflicting results are numerous,” they explained. “One explanation could be limited adherence to supplementation plans related to malodor and secondary gastrointestinal effects of fish oil.”

Bunout and colleagues attempted to expand the existing literature by examining the influence of fatty acid supplementation on albuminuria and cardiovascular risk factors such as pulse wave velocity (“a marker of arterial stiffness”) and triglycerides.

To limit the potential effects of “bad smell”, the study used a heavily deodorized oil containing omega-3 PUFA.

100 patients with CRF and urine albumin excretion of at least 30 mg / g creatinine took either 3,666 mg / day docosahexaenoic acid and eicosapentaenoic acid or a corn oil supplement for 3 months, the researchers finding that the omega-3 PUFA supplements “in taste and smell practically indistinguishable from corn oil. “

The results showed that patients who received the active supplement had a significant increase in their omega-3 index (3.1% to 5.5%) after 3 months.

Although supplementation did not appear to improve albuminuria (defined as a 20% reduction in urine albumen), the researchers found that participants who received omega-3 PUFAs maintained their pulse wave velocities while controls experienced an increase during follow-up . The triacylglycerol levels also decreased significantly in the omega-3 PUFA group.

Regarding side effects, 12 participants in the control group and 14 in the omega-3 PUFA group reported mild gastrointestinal symptoms.

Bunout and colleagues responded to these results and emphasized that omega-3 fatty acid supplementation has no effect on albuminuria.

“Given that the ultimate goal of any therapeutic intervention in CRF is to delay its progression, this new study adds to the evidence [omega-3 PUFA] have no role for this purpose, ”they claimed.

Still, they suggested that the positive effects seen with the other interventions are important for patients with CRF, since reducing arterial stiffness can help maintain kidney function and prevent heart failure, while reducing serum triglycerides can help prevent progression slow down the disease and lower the death rate.

“[Omega-3 PUFA] can lower the pulse wave velocity, blood pressure and triglyceride levels in patients with CKD and thus reduce the cardiovascular risk, ”the researchers concluded.

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