For the study, the team looked at four high-light lipoproteins (fats), low-density lipoproteins, total cholesterol, and triglycerides, which are biomarkers of cardiovascular disease. The data for their sample of 70,000 people comes from the UK Biobank, a large-scale cohort study that collected genetic and health information from half a million participants.
The team divided the sample into two groups: those who take fish oil supplements (approximately 11,000) and those who do not take fish oil supplements. They then performed a genome-wide scan for each group and tested 8 million genetic variants for comparison. After over 64 million tests, their results showed a significant genetic variant of the GJB2 gene.